Both have copper-infused memory foam and both are flippable mattresses with 4 on one side and 7 on the other on a firmness scale of 10.
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The Memory Foam Mattress features copper infused memory foam layers, support foam, and finally transition foam underneath. Hybrid also has dual-gauge pocket coils.
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Hybrid has improved Airflow by copper-gel infused foam, channelled transition layer and pocketed coils. No pocketed coils in memory foam.
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Memory foam cushions and supports compression areas. Adding coils increases support especially for bigger people. Support is much better on 16-gauge edge coils.
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While memory foam mattresses do provide that hugging feeling peculiar to memory foam, hybrids give less of that sinking feeling.
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The body sinks into the memory foam, so it doesn't bounce back as much, whereas due to the coils, the hybrid does have more bounce.
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Memory foam does have excellent motion isolation. Adding coils to memory foam does decrease that isolation to an extent, though.
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Memory foam mattress is 10", but with the benefit of memory foam and coils, the hybrid mattress is 13-inch high. Due to this, there is a $500 price difference.
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The memory foam mattress has a lifetime warranty, whereas the Layla hybrid mattress comes with a 10-year warranty.
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So if budget is a constraint, then obviously I will buy the memory foam mattress, but my choice is surely the hybrid mattress.
Picture Credit - Layla